Antonella Santuccione-Chadha

SGV Meeting 2026 · Scientific Programme

CHUV, Lausanne

• 25 November 2026 · 15:00Sex Bias in vitro
  Abstract

  Alzheimer’s disease presents significant sex and gender differences in its prevalence, progression, and clinical manifestations, highlighting the need for a more comprehensive and inclusive approach to neuroscience research. Biological factors, including hormonal influences, genetic mechanisms, and sex-specific cellular pathways, may contribute to differences in disease susceptibility and progression, while gender-related factors can influence risk exposure, diagnosis, and access to care.

  Integrating sex and gender perspectives into Alzheimer’s research is essential to improve our understanding of disease mechanisms and advance more precise and equitable therapeutic strategies. In this context, in vitro research offers valuable opportunities to investigate sex-specific cellular responses, molecular pathways, neuroinflammation, and interactions between neurons and other brain cell types under controlled experimental conditions. The use of sex-disaggregated biological materials and appropriately designed cellular models can help identify mechanisms that may otherwise remain undetected in conventional research approaches. Embedding sex and gender considerations throughout the research process, from experimental design to data interpretation, is therefore a critical step towards more representative and reproducible science. Strengthening sex- and gender-informed in vitro research can accelerate the development of targeted interventions and contribute to closing existing knowledge gaps in Alzheimer’s disease, ultimately supporting more effective and equitable brain health strategies.